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Impact of Curcumin on Traumatic Brain Injury and Involved Molecular Signaling Pathways

[ Vol. 11 , Issue. 2 ]

Author(s):

Tahereh Farkhondeh, Saeed Samarghandian*, Babak Roshanravan and Leila Peivasteh-roudsari   Pages 137 - 144 ( 8 )

Abstract:


Traumatic Brain Injury (TBI) is one of the main causes of mortality and morbidity worldwide with no suitable treatment. The present study was designed to review the present literature about the protective effects of curcumin and the underlying mechanism against TBI. All published English language papers from beginning to 2019 were selected in this study. The findings indicate that curcumin may be effective against TBI outcomes by modulating the molecular signaling pathways involved in oxidative stress, inflammation, apoptosis, and autophagy. However, more experimental studies should be done to identify all mechanisms involved in the pathogenesis of TBI. Patents for Curcumin and chronic inflammation and traumatic brain injury management (WO2017097805A1 and US9101580B2) were published. In conclusion, the present study confirmed the potential therapeutic impact of curcumin for treating TBI.

Keywords:

Curcumin, traumatic brain injury, inflammation, oxidative stress, apoptosis, autophagy.

Affiliation:

Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Noncommunicable Disease Research Center, Neyshabur University of Medical Sciences, Neyshabur, Medical Student, Student Research Committee, Birjand University of Medical Sciences, Birjand, Division of Food Safety and Hygiene, Department of Environmental Health, School of Public Health, Tehran University of Medical Sciences, Tehran

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