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Association Between Fat-soluble Vitamins and Lipid Profile in the Overweight Population

[ Vol. 11 , Issue. 1 ]

Author(s):

Sadegh Piran, Sahar Sarmasti, Mohammad Shabani, Naser Kakavandi, Bita Hosseni, Mohsen Khosravi, Shima Resaee, Elham Soltanmohammadi, Faezeh Naseri, Ghasem Ghasempour, Asghar Mohammadi and Mohammad Najafi*   Pages 56 - 62 ( 7 )

Abstract:


Background & Aims: It is well-known that the coronary artery stenosis is related to lipid profile. This is a descriptive cross-sectional study to investigate the relationship between the serum fat-soluble vitamins (A, E and D), circulating proprotein convertase subtilisin/kexin type 9 (PCSK9), and lipid profile in the study population.

Methods: A total of 120 overweight subjects were participated in this study. The circulating PCSK9 and vitamin D were measured by ELISA technique. The serum vitamin A and vitamin E amounts were simultaneously measured by the HPLC method. The Serum Small Dense LDLCholesterol (sdLDL-C) values were evaluated using heparin-Mg2+ precipitation technique. The lipid profile was measured by routine laboratory techniques.

Results: The serum vitamin E values correlated significantly to vitamin A (r= 0.47, P= 0.0001), VLDL-C (r= 0.30, P= 0.002), total cholesterol (r= 0.309, P= 0.001), PCSK9 (r= 0.233, P= 0.01) and total triglyceride (r= 0.61, P= 0.0001) values. The circulating PCSK9 values correlated significantly to LDL-C (r= 0.17, P= 0.05) and total cholesterol (r= 0.23, P= 0.009) values. However, there were not correlations between the levels of serum D and A vitamins, the serum LDL-C, sdLDL-C and total cholesterol values.

Conclusion: The data showed the correlations between serum vitamin E and PCSK9-related LDLC values lower than the normal range. Furthermore, the results suggested a nutritional need on the patents considering supplementation or fortification of vitamin E for the overweight subjects with higher LDL-C levels.

Keywords:

Vitamin E, vitamin D, vitamin A, sdLDL-C, LDL-C, PCSK9, overweight population.

Affiliation:

Biochemistry Department, Medical School, Iran University of Medical Sciences, Tehran, Biotechnology Department, Iran University of Medical Sciences, Tehran, Biochemistry Department, Medical School, Iran University of Medical Sciences, Tehran, Biochemistry Department, Medical School, Iran University of Medical Sciences, Tehran, Biochemistry Department, Medical School, Iran University of Medical Sciences, Tehran, Biochemistry Department, Medical School, Iran University of Medical Sciences, Tehran, Biochemistry Department, Medical School, Iran University of Medical Sciences, Tehran, Pharmaceutical Sciences Department, University of South Carolina, Biochemistry Department, Shahid Beheshi University, Biochemistry Department, Medical School, Iran University of Medical Sciences, Tehran, Tarbiat Modares University, Biochemistry Department, Biochemistry Department, Medical School, Iran University of Medical Sciences, Tehran



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